Over the years, a number of nicknames have been a part of Georgetown basketball. Here's a list of the nicknames and the players attributed to them. Note: Nicknames that were later popularized when a player was in the NBA are not included.
| Nickname | Belonging To... |
| Al | Italo Ablondi (1948-50) |
| Ba Ba | John Duren (1976-80) |
| Big Sky | Craig Shelton (1976-80) |
| Boo | Jim Barry (1962-66) |
| Buck | Sam Seymour (1954-57) |
| Buddy | Charles O' Donnell (1961-64) |
| Buddy | Francis O'Grady (1939-42) |
| Cheese | Alonzo Holloway (1973-74) |
| Chico | Irvin Church (1991-95) |
| Chief | Ray Corley (1946-49) |
| Chops | James Reed (1994-96) |
| Dean | Ed Lopata (1960-63) |
| Dino | Don Martin (1939-42) |
| Dippy | Paul Durkin (1945-46) |
| Doc | Tom O'Dea (1959-1962) |
| Doc | Marcus Derrickson (2015-18) |
| DSR | D'Vauntes Smith-Rivera (2012-16) |
| Dubber | Carroll Shore (1936-37) |
| Hap | Frank Farley (1923-25) |
| Hank | John Morano (1954-55) |
| Hollywood | Ron Lyons (1971-73) |
| Jed | Gerald Curry (1914-15) |
| King | Harry Kelly (1912-16) |
| L.J. | Daryl Peak (2014-17) |
| Mac | Matthew McClung (2018-20) |
| Max | Randolph Schmeling (1956-58) |
| Miggs | James Reilly (1942-47) |
| Primo | Amir Spears (2022-23) |
| Puddy | Brian Sheehan (1958-61) |
| Red | John McGuinness (1945-46) |
| Reds | Francis Daly (1937-40) |
| Rebel | Marvin Ritch (1911-12) |
| Rip | John Riches (1937-39) |
| Roy | Ronayne Waldron (1911-14) |
| Schlitz | Frank Schlosser (1908-12) |
| Sis | Leon Esenstadt (1933-36) |
| Sleepy | Eric Floyd (1978-82) |
| Snake | Bob Hannan (1968-71) |
| Stretch | Sylvester Goedde (1942-43) |
| Tay | Octavius Spann (2005-07) |
| Tippy | Jim Larkins (1950-53) |
| Tony | Brooke Beyer (1945-46) |
| Tug | James Fury (1911-12) |
| Vadi | Elvado Smith (1981-83) |
| Vee | Vincent Sanford (2009-11) |
| Ya-Ya | Cheikh Dia (1993-97) |
| Ziggie | Dick Zeitler (1968-71) |